How does it work?

PDRN activates the adenosine A2A receptors in the body. This causes an increase in the expression of vascular endothelial growth factor (VEGF) which is a type of growth factor that helps to stimulate the formation of new blood vessels. With more blood vessels, more blood can be brought to the area and this helps to improve skin repair and wound healing. This effect of PDRN is supported by a study which showed that blood flow greatly increased in skin flaps treated with PDRN. Furthermore, activating the adenosine A2A receptors also helps to reduce inflammation. It leads to a decrease in the production of inflammatory cytokines which are substances in the body that promote inflammation and causes an increase in the production of anti-inflammatory cytokines which are substances that help to reduce inflammation.

PDRN also increases the production of growth factors such as fibroblast growth factor (FGF) which stimulates the growth and activity of fibroblasts. Fibroblasts are cells that are required to regenerate important components of the skin such as collagen and glycosaminoglycans. Collagen is a protein that increases the strength and elasticity of the skin while glycosaminoglycans are molecules that improve hydration and moisture of the skin. Therefore, both play a major role in rejuvenating the skin and reducing signs of aging. The bad news is that the production of collagen and glycosaminoglycans decline with age, explaining the loss in moisture, elasticity and firmness of the skin. Therefore, it is no wonder that they are highly sought after today, which can be seen from the plethora of products ranging from collagen supplements to skincare products containing collagen or glycosaminoglycans. However, PDRN takes a different approach as instead of directly supplementing the skin with collagen or glycosaminoglycans, PDRN works by stimulating the skin to produce these important components to regenerate the skin from within.

Lastly, PDRN can be broken down by the body to generate nucleotides which are building blocks of DNA. These building blocks can then be used in DNA synthesis to form new DNA again. The increase in DNA synthesis stimulates cell growth and proliferation and hence leads to quicker tissue regeneration and wound healing. Furthermore, PDRN also helps protect cells from UV induced DNA damage. Exposure to ultraviolet radiation from the sun can damage DNA and cause premature signs of aging. PDRN helps to boost DNA repair and hence protects the skin from UV induced damage.

Is PDRN really that effective? The effectiveness of PDRN on healing and regeneration can be seen in the effects of PDRN on diabetic foot ulcers and skin graft donor sites. A study showed that the patient group treated with PDRN had nearly two times the rate of complete healing of difficult-to-heal diabetic foot ulcers. Furthermore, another study showed that administering PDRN decreased the healing times of skin graft donor sites. Therefore, it is no question that PDRN is a valuable substance for healing and regeneration and hence can be used to improve the aesthetic appearance of our skin. This explains why the Rejuran PDRN skin treatment is rising in popularity due to its anti-aging properties and ability to revitalize the skin.

Benefits of Rejuran PDRN on the aesthetic appearance of skin

  • Increase skin elasticity (Study showed that skin elasticity increased by 21.78% after treatment)
  • Increase skin hydration (Study showed that skin hydration increased by 14.69% after treatment)
  • Reduce skin surface roughness
  • Reduce skin pigmentation
  • Reduce fine lines and wrinkle depth
  • Skin normalization – Thickens and strengthens the skin to create a stronger defense barrier against factors that can cause premature aging of skin
  • Improve skin tone and reduce pores
  • Improve healing and reduce scar formation

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Who is suitable for Rejuran PDRN?

The use of Rejuran PDRN is not limited to the older age group displaying signs of skin aging. It is also suitable for people suffering from acne who have damaged and acne scarred skin. As Rejuran PDRN can smoothen the skin, improve healing and reduce scarring, it can also help to reduce the appearance of acne scars. Furthermore, people with large pores and oily skin can also greatly benefit from this treatment. Therefore, Rejuran PDRN can benefit people of all ages who want to improve the appearance of their skin.

Types of Rejuran Treatment

There are different types of Rejuran treatment, each type used to target a different skin problem or area. 

  1. Rejuran Healer which can be used all around the face to rejuvenate the skin.
  2. Rejuran S which better targets scarring and hence is more suitable for treating acne scars.
  3. Rejuran I which is more suitable for the area under the eyes.

You should consult your dermatologist on which is the most suitable for your skin condition.

Rejuran Treatment process

Numbing cream is first applied to the face. After numbing the area, the doctor will use a fine needle to inject very small amounts of the product under the skin. This is followed by LED Red or Infrared Light therapy to cut down the redness and swelling. It is important to note that time is required for the results of Rejuran PDRN to show as it takes about 4 weeks for any visible improvements to your skin. The recommended frequency of the treatment is 3-4 times, each time being 2-4 weeks apart.  After that, the skin treatment can be repeated every 6-9 months for maintenance of the skin. You should consult your dermatologist for the recommended treatment plan and frequency specific to your skin condition.

Side effects of Rejuran Treatment

There may be some redness and swelling after the skin treatment as well as the appearance of small bumps at the injection sites. Mild bruising may also occur but there is no need to worry as these side effects are temporary and will eventually resolve, making Rejuran PDRN an effective and safe treatment option to rejuvenate your skin. In a study investigating the effects of Rejuran PDRN, no important adverse effects were noted. However, it is still important to consult your dermatologist beforehand and to notify your dermatologist if you have done any other skin treatments and fillers as they may cross react with the Rejuran PDRN treatment.


In conclusion, regaining youthful looking skin may not be an impossible task with the Rejuran PDRN treatment. With advances in skin treatments, we are now one step closer to addressing our skin problems and attaining better skin. If you are struggling with aged skin or other skin problems like acne scarring, Rejuran PDRN is a potential skin treatment you can consider. Its effect goes beyond simply filling up wrinkles and fine lines but stimulates skin regeneration and restoration to turn back the clock and achieve more youthful looking skin. If you are considering this treatment, you can consult your dermatologist for further details.